The Week 6 NFL schedule has several twists, with no Thursday Night Football and a pair of games on Monday as the league navigates the COVID-19 pandemic. Despite the changes, there are still plenty of matchups with potential postseason implications. The Week 6 NFL odds from William Hill list Aaron Rodgers and the Packers as two-point favorites over Tom Brady and the Buccaneers. The latest NFL spreads also list the Chiefs at -3 at Buffalo in a battle of AFC contenders. 

Which NFL point spreads should you target with your Week 6 NFL bets? And which NFL Vegas spreads are way off? All of the Week 6 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 6 NFL picks now.

The SportsLine Projection Model simulates every NFL game 10,000 times and is up over $7,500 for $100 players on its top-rated NFL picks since its inception five-plus years ago.

It’s off to a strong 10-5 roll on top-rated NFL picks this season. The model enters Week 6 on an incredible 106-70 roll on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, it has examined the latest Week 6 NFL odds and NFL betting lines, simulated every snap, and its predictions are in. Head to SportsLine now to see them all.

Top NFL predictions for Week 6

One of the top Week 6 NFL predictions the model recommends: The Ravens (-8 at William Hill) cover the spread on the road against the Eagles. Philadelphia is 1-3-1 straight-up this season and just 1-4 against the spread. The Ravens, meanwhile, have a 4-1 straight-up record with a 3-1-1 mark against the spread. 

Philly has been hit hard by injuries and could be missing multiple receivers. The Eagles could be without star offensive lineman Lane Johnson as well after he hurt his ankle against Pittsburgh last week. Baltimore hasn’t been fazed playing on the road, as it has covered in six of its last seven away games. SportsLine’s model has the Ravens covering the spread well over 60 percent of the time, with the over (46.5) clearing by half-a-point. 

Another one of the top Week 6 NFL picks from the model: The Dolphins (-8) cover at home against the winless Jets. Despite calls to turn to Tua Tagovailoa at quarterback, veteran Ryan Fitzpatrick has kept Miami in contention. The Dolphins (2-3) have won two of their last three and own a 3-2 record against the spread this season.

The Jets, meanwhile, are in disarray. They haven’t won or covered this season, continuing the trend of being the NFL’s worst team against the spread since 2018 with a a 12-24-1 mark since that point. New York is hoping to get quarterback Sam Darnold (shoulder) back, but the model doesn’t see his presence mattering much. Miami covers in well over 50 percent of simulations, while you can also bank on the over (47.5) because that hits well over 50 percent of the time. 

How to make Week 6 NFL picks 

The model also has made the call on every other game on the Week 6 NFL schedule. It’s also identified a Super Bowl contender that goes down hard. You can only get every pick for every game here.

What NFL picks can you make with confidence in Week 6? And which Super Bowl contender goes down hard? Check out the latest NFL odds from William Hill below and then visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that is up over $7,500 on its top-rated NFL picks. 

NFL odds, matchups for Week 6

Denver Broncos at New England Patriots (-9)
Chicago Bears at Carolina Panthers (-2.5, 44.5)
Detroit Lions at Jacksonville Jaguars (+3.5, 54.5)
Atlanta Falcons at Minnesota Vikings (-3.5, 55.5)
Houston Texans at Tennessee Titans (-5.5)
Washington Football Team at New York Giants (-3, 43)
Cleveland Browns at Pittsburgh Steelers (-3.5, 51)
Baltimore Ravens at Philadelphia Eagles (+8, 46.5)
Cincinnati Bengals at Indianapolis Colts (-8, 46.5)
New York Jets at Miami Dolphins (-8, 47.5)
Green Bay Packers at Tampa Bay Buccaneers (+2, 54)
Los Angeles Rams at San Francisco 49ers (+3.5, 50)
Kansas City Chiefs at Buffalo Bills (+3)
Arizona Cardinals at Dallas Cowboys (+2.5, 54.5)

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