Picking winners in the NFL is already a challenge, but when you factor in the coronavirus pandemic, it’s harder than ever. The Titans came back from a 17-day layoff as they dealt with a COVID-19 outbreak at their facility to deliver a surprising 42-16 smashing of the Bills on Tuesday night. How should you approach the Titans with your Week 6 NFL office pool picks? Tennessee was one of five teams to win as outright underdogs for the second consecutive week, but can you expect to see that trend continue as you make your Week 6 NFL confidence pool picks?

The Chiefs losing as 10.5-point favorites against the Raiders last week threw a wrench into NFL football pool picks everywhere. Before you make your NFL picks, you need to see the Week 6 NFL football pool picks from SportsLine’s proven model. 

This model, which simulates every NFL game 10,000 times, ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. It’s off to a hot 53-23 start to the 2020 season, and anyone who has followed it is way up.

Now, the model has simulated the entire Week 6, 2020 NFL schedule 10,000 times and generated its optimal NFL pick’em plays. Go to SportsLine to see them.

Top Week 6 NFL office pool predictions

One of the top Week 6 NFL pick’em predictions from the model: Minnesota gets a comfortable win against the Falcons. The Vikings are off to a 1-4 start, but they recorded a win in Week 4 against the Texans that was sandwiched between a pair of one-point losses to the undefeated Titans and Seahawks.

Now, they’ll take on an Atlanta squad that just cleaned house after an 0-5 start. If you take away a brutal performance against the Colts in which the Vikings scored 11 points and had 175 yards, Minnesota’s offense is averaging a sparkling 30.3 points and 426.3 yards per game this season. They’ll take on a defense that ranks 30th in points allowed and 31st in yards allowed.

The model predicts that Kirk Cousins throws for well over 250 yards and two touchdowns against Atlanta on Sunday. Even though Dalvin Cook is likely to miss the game with an adductor strain, it also predicts that the Vikings still rush for over 120 yards, with backup Alexander Mattison going for 79 yards on average. That’s why the model says the Vikings win outright in over 60 percent of simulations.

How to make Week 6 NFL office pool picks

The model also made the call on every other Week 6 game and has strong picks for potentially close matchups like Bears vs. Panthers and Packers vs. Buccaneers. It’s also calling for a Super Bowl contender to go down hard. You can only see all of the model’s NFL pool picks here. 

So who should you pick in every Week 6 NFL game? And which Super Bowl favorite goes down hard? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks three of the last four years and is 53-23 this season.


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