And plenty of attention will be on Icardi’s wife Wanda Nara before, during and after the match.
Nara is Icardi’s wife and agent and regularly speaks on behalf of the player.
She has often spoken of transfer rumours linking Icardi to different clubs, while helped broker contract talks with Inter that has so-far kept the Argentina international happy.
Icardi is Inter’s star man and will come up against Juventus gem Ronaldo tonight in Turin.
Icardi and Ronaldo are also battling it out for the golden boot in Italy this term.
But Nara is not a fan of the Portugal international and stood by her husband when asked to compare their goalscoring records.
“It’s not easy to adapt to Italian football,” she said last month.
“Icardi is on a par with Cristiano Ronaldo. He played three games fewer than CR7 (which is why he has fewer goals).
“I’d like to see Ronaldo on the bench against Genoa (in November).
“Mauro didn’t play against them and he could have scored five goals.”
Nara also claimed her husband is friends with fellow-Argentine Lionel Messi – who has been a rival of Ronaldo at the top of world football for a decade.
“Mauro has great memories of Barcelona, he grew up there and he is a very close friend of Messi,” she added.
Juventus vs Inter kicks off at 19:30 tonight and you can follow the game LIVE here with Express Sport.