Reports claim Pogba has suffered a ‘little injury’ that forced him do ‘indoor work’ instead of taking part in full training.
That is despite the fact he played 90 minutes in Wednesday’s 2-1 victory over Juventus in the Champions League.
Manager Jose Mourinho already has concerns over the fitness of Romelu Lukaku, although the Belgian did train on Friday and remains in contention.
Alexis Sanchez also trained with the group despite picking up a slight knock in Turin.
“Lukaku is training with the team this morning,” Mourinho said.
“We have of course one more session tomorrow, but if the answer is positive, he’s ready.
“But in this moment, I can only say he trains with the team. I don’t know his answer.”
United go to neighbours and Premier League leaders Manchester City looking to close the gap on the top four.
Pogba is yet to miss a single league game in the current campaign and is United’s second-highest scorer in all competitions with five goals.
Mourinho subsists his side are going to the Etihad with the intention of taking the game to their free-scoring opponents.
Pep Guardiola’s City have scored a whopping 33 goals already this season and have scored six in their last two outings.
But Mourinho promised fans he would not park the bus.
“We are going to try (and win),” he said.
“I cannot say we are going to be successful in our motivations, in our desire, but we played two difficult matches away against two very good teams, Chelsea and Juventus, and we managed to get good results.
“Even if the good results were not in our pockets, the performances were there, the positive attitude was there.
“So we are going to try but City are a very powerful team.
“If we draw the gap is still nine points, if we lose it’s 12, so I don’t think that is the way to look at the match.
“We have to just think about the match, is difficult enough as an isolated event, if you want to put that match into the context of where we are and where we can be.
“I want to play it as an isolated match, a difficult match against a difficult team, but they will also think it’s a difficult match for them.”