The two sides go head-to-head at Anfield at 4pm and there are doubts over whether Pogba will play.
He’s fallen out with Manchester United boss Jose Mourinho and was only recalled for a meaningless Champions League clash with Valencia in midweek.
Despite that – and his poor form – Murphy believes Liverpool won’t want to see Pogba on the pitch.
“The Liverpool dressing room will be happier if he’s not on the Manchester United teamsheet at Anfield this afternoon,” the ex-midfielder told the Mail.
“On a good day, Pogba has all the attributes — he’s strong, skilful, quick, technically very good. He can run in behind or play the ball around you.
“No disrespect to Nemanja Matic or Marouane Fellaini but no United midfielder can hurt you like Pogba. However badly he is playing, Jurgen Klopp’s players won’t be pleased to see him.
“I got an insight into Pogba by watching France’s World Cup semi-final against Belgium. I saw Didier Deschamps talking to him on the touchline and Pogba was outstanding in the second half.
“He showed defensive discipline, often dropped deep to become the third centre back and outjumped Fellaini. It showed me that Pogba has the ability to be anything he wants given the right manager, system and team-mates.
“His relationship with Jose Mourinho has been one of the storylines of the season. I have no inside knowledge of that but if I was Manchester United, I wouldn’t sell him.
“He is unique in what he can offer and has years ahead of him. It makes no financial sense to pack him off to Juventus in January.
“Why has Pogba struggled? Probably a mixture of things. His role in the team, Mourinho’s style of management and, of course, players have to help themselves as well. But just because Pogba wants to play attacking, creative football, it doesn’t mean he can’t do other things if handled right. I’ve seen it.
“I don’t believe for a second he goes on to the pitch thinking he’s not going to try. I see subconscious lethargy. It comes when players aren’t happy, the shoulders drop and you can get frustrated if team-mates aren’t on the same wavelength.”
Liverpool are 16 points above United in the Premier League table and they will return to the summit with victory this afternoon.
Murphy has backed his old club to come out on top but fears Mourinho will go backs-to-the-wall at Anfield.
“Klopp has good reason not to underestimate United,” he added.
“He couldn’t beat them last season and more recently Mourinho has found a way to get results at Chelsea and Juventus. United are also fresher, resting players for their midweek game in Europe.
“If both teams play at their best, Liverpool will win. Mourinho doesn’t mix up his tactics enough but he’ll be happy to take the sting out of the game and has matchwinners such as Marcus Rashford and Romelu Lukaku at the end.”