Kane will captain England this afternoon as the Three Lions seek a place on the UEFA Nations League finals.
The Tottenham forward has currently notched 19 goals for his country, 34 strikes short of Rooney’s record of 53.
That total will not become any more imposing, however, as Rooney earned his 120th – and final – international cap on Thursday evening.
The 33-year-old was given an honorary send-off at Wembley, playing the final 32 minutes of England’s 3-0 win over USA.
Rooney, for so long a pugnacious, rounded centre-forward leaves in his wake a man as aptly gifted to succeed him.
After Thursday’s game, Rooney predicted that Kane would eclipse his scoring feats.
“I look forward to presenting him with the trophy,” he told Radio 5 live.
Kane and FA chairman Greg Clarke made a presentation to Rooney before the game, and the former United forward revealed: “I asked Harry to present me with the award because I believe he will beat my goalscoring record.
“It was great to be out there in front of the fans again and it was special for me and my family.”
Kane has now responded to Rooney’s pressurising comments.
“It is definitely possible,” said Kane, who won the 2018 World Cup golden boot.
“It is still a fair bit away. I don’t like to set my targets that far ahead in the future because a lot can happen.
“We will see over the years how many goals I have got.
“Hopefully I will still be fit and healthy and getting selected by the manager.
“It is achievable but not something I’m thinking about too much right now.”