All four cruiserweight titles are on the line as the Evertonian takes on the pound-for-pound star.
Bellew has declared that he will retire after this fight, as he looks to become a two-time cruiserweight world champion.
Usyk is also likely to leave the division after this fight, as he targets a move up to heavyweight.
On the undercard, Anthony Crolla fights in a final eliminator for the WBA world lightweight title, Ricky Burns and Scotty Cardle collide in a lightweight bout, Josh Kelly continues his rise through the ranks, and Dave Allen looks to build on two impressive back-to-back KO wins.
Tony Bellew vs Oleksandr Usyk LIVE results:
Sam Hyde vs Richard Riakporhe
Dave Allen vs Ariel Esteban Bracamonte
Josh Kelly vs Walter Fabian Castillo
Ricky Burns vs Scotty Cardle
Anthony Crolla vs Daud Yordan
Oleksandr Usyk vs Tony Bellew