Aubameyang and Lacazette are yet to start as a pair under Unai Emery but will get their chance today against the Terriers.
Emery has made three changes to the side which drew 2-2 against Manchester United on Wednesday.
Stephan Lichtsteiner comes in for the injured Rob Holding.
Granit Xhaka returns to midfield after suspension and replaces Aaron Ramsey.
And Lacazette starts with Alex Iwobi dropping to the bench.
Huddersfield boss David Wagner also makes three changes following their defeat to Bournemouth.
Tommy Smith, Chris Lowe and Danny Williams all come into the team.
Florent Hadergjonaj, Pjilip Billing and Erik Durm drop out.
Arsenal: Leno, Bellerin, Sokratis, Mustafi, Kolasinac, Lichtsteiner, Torreira, Xhaka, Guendouzi, Lacazette, Aubameyang
Subs: Cech, Elneny, Koscielny, Mkhitaryan, Iwobi, Monreal, Nketiah
Huddersfield: Lossl, Smith, Zanka, Kongolo, Schindler, Lowe, Hogg, Williams, Mooy, Pritchard, Depoitre
Subs: Hamer, Bacuna, Kachunga, Sobhi, Mbenza, Hadergjonaj, Durm